1977•Hormone and Metabolic ResearchRequires access
Decreased Sensitivity to Insulin in White Adipose Tissue from Adrenalectomised Rats
Susan J. Smith, E D Saggerson
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Abstract
The ability of insulin to increase both [14C]-glucose incorporation into fatty acids and pyruvate dehydrogenase activity in incubated rat epididymal adipose tissues was considerably lessened after adrenalectomy. Insulin antagonism of adrenaline-stimulated lipolysis in isolated fat cells was abolished after adrenalectomy. Percentage stimulation of lipolysis above basal by adrenaline was not appreciably altered by adrenalectomy.