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Adverse Interactions Encountered when Using Trazodone to Treat Insomnia Associated with Fluoxetine

Alan Metz, Richard I. Shader

Abstract

The authors report adverse interactions encountered when using low dose (25-75 mg) trazodone to treat insomnia associated with fluoxetine. Sixteen patients had good hypnotic responses to trazodone, but five needed to stop the medication due to excessive sedation. Three cases are described.

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Key concepts: Trazodone, Fluoxetine, Hypnotic, Sedation, Insomnia, Adverse effect, Medicine, Anesthesia