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2008•Experimental Cell BiologyRequires access

The Endothelium of the High Endothelial Venule: A Specialized Endothelium with Unique Properties

Georg Kraal, Adrian M. Duijvestijn, Hans R. Hendriks

Open publisher page 32 citations

Abstract

High endothelial venules (HEV) in lymphoid organs are specialized to facilitate the passage of lymphocytes into lymphoid parenchyma. This is accomplished by a ligand-receptor system on the endothelium and lymphocytes, which differs between lymph nodes and Peyer's patch. Experiments discussed in this paper show that other non-HEV-derived endothelial cells can acquire the characteristics of HEV and that HEV may differentiate under influences from their local micro-environments.

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What this paper is about

High endothelial venules (HEV) in lymphoid organs are specialized to facilitate the passage of lymphocytes into lymphoid parenchyma. This is accomplished by a ligand-receptor system on the endothelium and lymphocytes, which differs between lymph nodes and Peyer's patch. Experiments discussed in this paper show that other non-HEV-derived endothelial cells can acquire the characteristics of HEV and that HEV may differentiate under influences from their local micro-environments.

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OpenAlex reports 32 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

High endothelial venules (HEV) in lymphoid organs are specialized to facilitate the passage of lymphocytes into lymphoid parenchyma. This is accomplished by a ligand-receptor system on the endothelium and lymphocytes, which differs between lymph nodes and Peyer's patch. Experiments discussed in this paper show that other non-HEV-derived endothelial cells can acquire the characteristics of HEV and that HEV may differentiate under influences from their local micro-environments.

Key concepts: High endothelial venules, Venule, Endothelium, Lymphatic system, Lymphatic Endothelium, Lymph, Biology, Parenchyma

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