1974•The Journal of Clinical Endocrinology & MetabolismRequires access

Inhibition by Apomorphine of Prolactin Secretion in Patients with Elevated Serum Prolactin

Joseph B. Martin, Samarthji Lal, G. Tolis, Henry G. Friesen

Abstract

Apomorphine caused significant depression in prolactin (hPRL) in each of 6 patients with elevated serum levels, including 4 with hPRL-secreting tumors. A parallel rise in growth hormone (hGH) occurred in 5 of the 6 subjects. These results suggest that: i) a dopaminergic mechanism regulates hPRL and hGH secretion; and ii) that abnormal hPRL secretory states remain responsive to dopaminergic control.

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Key concepts: Endocrinology, Prolactin, Internal medicine, Apomorphine, Dopaminergic, Secretion, Hormone, Prolactin cell