2006•Journal of BacteriologyOpen access

Interference between Streptococcus pneumoniae and Staphylococcus aureus : In Vitro Hydrogen Peroxide-Mediated Killing by Streptococcus pneumoniae

Gili Regev‐Yochay, Krzysztof Trzciński, Claudette M. Thompson, Richard Malley, Marc Lipsitch

Abstract

The bactericidal activity of Streptococcus pneumoniae toward Staphylococcus aureus is mediated by hydrogen peroxide. Catalase eliminated this activity. Pneumococci grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were nonpneumococcal streptococci. These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies.

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Key concepts: Streptococcus pneumoniae, Microbiology, Staphylococcus aureus, Biology, Hydrogen peroxide, Streptococcus, Catalase, In vitro