Botcinins A, B, C, and D, Metabolites Produced by Botrytis c inerea , and Their Antifungal Activity against Magnaporthe g risea , a Pathogen of Rice Blast Disease
Hiroko Tani, Hiroyuki Koshino, Emi Sakuno, Hiromitsu Nakajima
Abstract
Hiroko Tani, Hiroyuki Koshino, Emi Sakuno, Hiromitsu Nakajima
Abstract
Four new metabolites, botcinins A-D, were isolated from the culture filtrate of a strain of Botrytis cinerea. Their structures were determined by spectroscopic methods, mainly NMR techniques, molecular modeling, and the modified Mosher's method. They exhibited antifungal activities against Magnaporthegrisea, a pathogen of rice blast disease. Botcinins B and C have a MIC of 12.5 microM, and botcinins A and D are not active below 100 microM.
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Four new metabolites, botcinins A-D, were isolated from the culture filtrate of a strain of Botrytis cinerea. Their structures were determined by spectroscopic methods, mainly NMR techniques, molecular modeling, and the modified Mosher's method. They exhibited antifungal activities against Magnaporthegrisea, a pathogen of rice blast disease. Botcinins B and C have a MIC of 12.5 microM, and botcinins A and D are not active below 100 microM.
Key concepts: Magnaporthe grisea, Botrytis cinerea, Antifungal, Botrytis, Stereochemistry, Fungal pathogen, Strain (injury), Blast disease