2009•Cell Biology InternationalOpen access

TNF superfamily: Costimulation and clinical applications

Dass S. Vinay, Byoung S. Kwon

Abstract

The molecules concerned with costimulation belong either to the immunoglobulin (Ig) or tumor necrosis factor (TNF) superfamily. The tumor necrosis superfamily comprises molecules capable of providing both costimulation and cell death. In this review we briefly summarize certain TNF superfamily receptor-ligand pairs that are endowed with costimulatory properties and their importance in health and disease.

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Key concepts: Immunoglobulin superfamily, SUPERFAMILY, Tumor necrosis factor alpha, Tumor necrosis factor receptor, Immunology, Receptor, Biology, Cell biology