1983•Antimicrobial Agents and ChemotherapyOpen access

Mechanism of resistance to some cephalosporins in Staphylococcus aureus

Mari Kono, Masanori Sasatsu, Koji Ohara, Yasuki Shiomi, T Hayasaka

Abstract

The mechanism of resistance to some cephalosporins in Staphylococcus aureus strains was investigated with high-pressure liquid chromatography and nuclear magnetic resonance spectrometry. Drug inactivation by penicillinase was found to be the main mechanism of resistance to cefazolin, cephaloridine, and cephalothin in S. aureus.

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Available abstract

Key concepts: Cephaloridine, Cefazolin, Staphylococcus aureus, Cephalosporin, Microbiology, Cefoxitin, Drug resistance, Mechanism (biology)