2005•Pediatric TransplantationRequires access

Tissue typing for hematopoietic cell transplantation: Newer techniques and newer antigens for which cross‐matching is helpful

Robert Iannone, Stella M. Davies

Abstract

Refinements in human leukocyte antigen (HLA) typing techniques for hematopoietic cell transplantation (HCT) have permitted a more precise assessment of donor-recipient histocompatibility, which has impacted transplantation outcomes. More recently, differences in transplant outcomes associated with killer immunoglobulin-like receptor compatibility have emphasized the potential importance of natural killer (NK) cell typing in HCT. This article reviews the current state of the art for HCT donor selection based on both HLA and NK cell typing.

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Key concepts: Human leukocyte antigen, Typing, Tissue typing, Hematopoietic cell, Immunology, Medicine, Histocompatibility, Transplantation