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Depth-Resolved Determination of the Absorption Coefficient by Photoacoustic Spectroscopy within a Hydrogel

Christian Kopp, Reinhard Nießner

Open publisher page 7 citations

Abstract

A semiempirical method for the inversion of photoacoustic signal profiles is presented, which allows the depth-resolved determination of the absorption coefficient of nonscattering samples. Experimentally determined reference profiles were used to reconstruct photoacoustic signal profiles measured with an indirect photoacoustic sensor system. The system was calibrated with homogeneous hydrogel samples. The developed inversion method was applied to layered hydrogel samples (two or three layers) and to a sample with continuously varying absorption properties. Particularly the investigation of the latter sample showed that the depth resolution of the used photoacoustic detection system is about 10 μm.

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What this paper is about

A semiempirical method for the inversion of photoacoustic signal profiles is presented, which allows the depth-resolved determination of the absorption coefficient of nonscattering samples. Experimentally determined reference profiles were used to reconstruct photoacoustic signal profiles measured with an indirect photoacoustic sensor system. The system was calibrated with homogeneous hydrogel samples. The developed inversion method was applied to layered hydrogel samples (two or three layers) and to a sample with continuously varying absorption properties. Particularly the investigation of the latter sample showed that the depth resolution of the used photoacoustic detection system is about 10 μm.

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Available abstract

A semiempirical method for the inversion of photoacoustic signal profiles is presented, which allows the depth-resolved determination of the absorption coefficient of nonscattering samples. Experimentally determined reference profiles were used to reconstruct photoacoustic signal profiles measured with an indirect photoacoustic sensor system. The system was calibrated with homogeneous hydrogel samples. The developed inversion method was applied to layered hydrogel samples (two or three layers) and to a sample with continuously varying absorption properties. Particularly the investigation of the latter sample showed that the depth resolution of the used photoacoustic detection system is about 10 μm.

Key concepts: Photoacoustic imaging in biomedicine, Chemistry, Photoacoustic spectroscopy, Attenuation coefficient, Photoacoustic effect, Analytical Chemistry (journal), Absorption (acoustics), Homogeneous

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