2010•The Open Dermatology JournalOpen access

Adherens Junctions, Desmosomes and Tight Junctions in Epidermal Barrier Function

Johanna M. Brandner, Marek Haftek, Carien M. Niessen

Abstract

The skin is an indispensable barrier which protects the body from the uncontrolled loss of water and solutes as well as from chemical and physical assaults and the invasion of pathogens. In recent years several studies have suggested an important role of intercellular junctions for the barrier function of the epidermis. In this review we summarize our knowledge of the impact of adherens junctions, (corneo)-desmosomes and tight junctions on barrier function of the skin.

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Key concepts: Adherens junction, Tight junction, Septate junctions, Barrier function, Cell junction, Epidermis (zoology), Skin barrier, Desmosome