2001•Antimicrobial Agents and ChemotherapyOpen access

Azasordarins: Susceptibility of Fluconazole-Susceptible and Fluconazole-Resistant Clinical Isolates of Candida spp. to GW 471558

Manuel Cuenca‐Estrella, Emilia Mellado, Teresa M. Dı́az-Guerra, Araceli Monzón, Juan L. Rodrı́guez-Tudela

Abstract

The in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candida spp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreased susceptibility to azoles. Candida krusei, Candida parapsilosis, Candida lusitaniae, and Candida guilliermondii are resistant to GW 471558 in vitro (MICs, >128 microg/ml).

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Key concepts: Candida krusei, Fluconazole, Candida tropicalis, Microbiology, Candida parapsilosis, Candida glabrata, Ketoconazole, Itraconazole