1977•Postgraduate Medical JournalOpen access

Tumoral calcinosis: a manifestation of extreme metastatic calcification occurring with 1, alpha-hydroxycholecalciferol therapy

G. S. Walker, A. M. Davison, Munro Peacock, M. S. F. McLachlan

Abstract

Two cases are reviewed, both of which developed tumoral calcinosis whilst receiving 1, alpha-hydroxy-cholecalciferol therapy. Tumoral calcinosis is an extreme form of peri-articular calcification, and its occurrence in patients with chronic renal failure is unusual. These peri-articular masses developed around the shoulders in both patients, and the action of 1, alpha-hydroxycholecalciferol as a possible factor promoting this form of metastatic calcification is discussed.

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Key concepts: Medicine, Tumoral calcinosis, Calcinosis, Calcification, Metastatic calcification, Shoulders, Cholecalciferol, Alpha (finance)