1984•Clinical and Experimental HypertensionRequires access

Dynorphin-(1–13)-Like Immunoreactivity in Central Nervous System and Pituitary Gland of Spontaneously Hypertensive Rats

F.Jay Kouchich, Raymond M. Quock, Liang‐Fu Tseng

Abstract

We determined by radioimmunoassay concentration of dynorphin-(1-13)-like immunoreactivity in the central nervous system and pituitary gland of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto rats (WKYs). Compared to WKYs, SHRs had significantly lower levels of dynorphin-(1-13)-like immunoreactivity in the hypothalamus and pituitary gland. However, such immunoreactivity in the cerebral cortex, caudate nucleus, diencephalon, brainstem and spinal cord of SHRs and WKYs were similar.

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Key concepts: Diencephalon, Internal medicine, Endocrinology, Dynorphin, Central nervous system, Brainstem, Hypothalamus, Pituitary gland