1986•European Journal of PharmacologyOpen access
Tolerance to anti-pentylenetetrazol effects following chronic diazepam
Susan F. Gonsalves, Dorothy W. Gallager
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Abstract
Continuous release of diazepam from subcutaneously implanted silastic capsules provided significant protection against pentylenetetrazol seizures in rats for up to 3 weeks. However, the degree of protection seen after 3 weeks of exposure to diazepam was significantly less than after 1 h. These data suggest that continuous exposure to constant low levels of diazepam results in the development of partial tolerance which is not sufficient to eliminate significant anticonvulsant effects.