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Inhibition of Transcriptional Regulator Yin-Yang-1 by Association with c-Myc

Ajay Shrivastava, Shireen Saleque, Ganjam V. Kalpana, Steven E. Artandi, Stephen P. Goff, Kathryn Calame

Abstract

Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.

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Key concepts: YY1, Repressor, Activator (genetics), Regulator, Transcription (linguistics), Transcriptional regulation, Molecular biology, Gene