S2‐01‐05: Interactions between tau phosphatases and tau kinases in formation of tau hyperphosphorylation in Alzheimer's disease

The abnormal hyperphosphorylation of tau is one of the key puzzles in Alzheimer's disease brain. It is believed that this process is caused by an imbalanced activity of protein kinases and protein phosphatases. Based on the data generated from post-mortem human brains, cellular and in vivo models of AD from our and other groups, the recent achievements on the possible synergistic role of protein phosphatase 2A and protein kinases p70S6K, PKB, GSK3, JNK and /or ERK towards tau is reviewed in this presentation. Multiple drug targets should be addressed at the same time in order to efficiently treat the disease.