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2003•Antimicrobial Agents and ChemotherapyOpen access

In Vitro Activity of Linezolid against Slowly Growing Nontuberculous Mycobacteria

Barbara A. Brown‐Elliott, Christopher J. Crist, Linda Mann, Rebecca W. Wilson, Richard J. Wallace

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Abstract

MICs of linezolid in broth microdilutions were tested against 341 slowly growing nontuberculous mycobacteria (NTM) belonging to 15 species. The proposed linezolid susceptibility MICs for all Mycobacterium marinum, Mycobacterium szulgai, Mycobacterium kansasii, Mycobacterium malmoense, and Mycobacterium xenopi isolates and for 90% of Mycobacterium gordonae and Mycobacterium triplex isolates were </=8 micro g/ml. Linezolid has excellent therapeutic potential against most species of NTM.

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What this paper is about

MICs of linezolid in broth microdilutions were tested against 341 slowly growing nontuberculous mycobacteria (NTM) belonging to 15 species. The proposed linezolid susceptibility MICs for all Mycobacterium marinum, Mycobacterium szulgai, Mycobacterium kansasii, Mycobacterium malmoense, and Mycobacterium xenopi isolates and for 90% of Mycobacterium gordonae and Mycobacterium triplex isolates were </=8 micro g/ml. Linezolid has excellent therapeutic potential against most species of NTM.

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Available abstract

MICs of linezolid in broth microdilutions were tested against 341 slowly growing nontuberculous mycobacteria (NTM) belonging to 15 species. The proposed linezolid susceptibility MICs for all Mycobacterium marinum, Mycobacterium szulgai, Mycobacterium kansasii, Mycobacterium malmoense, and Mycobacterium xenopi isolates and for 90% of Mycobacterium gordonae and Mycobacterium triplex isolates were </=8 micro g/ml. Linezolid has excellent therapeutic potential against most species of NTM.

Key concepts: Mycobacterium kansasii, Linezolid, Nontuberculous mycobacteria, Mycobacterium marinum, Microbiology, Mycobacterium, Biology, Mycobacterium chelonae

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