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Typ-IV-Allergie auf Kortikosteroide

Tobias Plaza, Gabriele C. Nist, Peter Von Den Driesch

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Abstract

HISTORY AND CLINICAL FINDINGS: A 48-year-old woman developed a skin rash after taking glucocorticoids. INVESTIGATIONS: Positive patch tests revealed type IV allergy (delayed reaction) to several glucocorticoids. In addition an eczema-like rash was produced by an oral provocation test with triamcinolone, although the patch test for this drug had been negative. TREATMENT AND COURSE: We recommended avoidance of the positively-tested corticosteroids and issued a corresponding allergy pass. CONCLUSION: Type IV allergy to glucocorticoids is rare but should be considered whenever patients develop a skin rash after the use of corticosteroids.

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What this paper is about

HISTORY AND CLINICAL FINDINGS: A 48-year-old woman developed a skin rash after taking glucocorticoids. INVESTIGATIONS: Positive patch tests revealed type IV allergy (delayed reaction) to several glucocorticoids. In addition an eczema-like rash was produced by an oral provocation test with triamcinolone, although the patch test for this drug had been negative. TREATMENT AND COURSE: We recommended avoidance of the positively-tested corticosteroids and issued a corresponding allergy pass. CONCLUSION: Type IV allergy to glucocorticoids is rare but should be considered whenever patients develop a skin rash after the use of corticosteroids.

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Available abstract

HISTORY AND CLINICAL FINDINGS: A 48-year-old woman developed a skin rash after taking glucocorticoids. INVESTIGATIONS: Positive patch tests revealed type IV allergy (delayed reaction) to several glucocorticoids. In addition an eczema-like rash was produced by an oral provocation test with triamcinolone, although the patch test for this drug had been negative. TREATMENT AND COURSE: We recommended avoidance of the positively-tested corticosteroids and issued a corresponding allergy pass. CONCLUSION: Type IV allergy to glucocorticoids is rare but should be considered whenever patients develop a skin rash after the use of corticosteroids.

Key concepts: Rash, Provocation test, Medicine, Triamcinolone acetonide, Allergy, Dermatology, Patch test, Drug allergy

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