2000•Pharmacology & TherapeuticsRequires access

The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine

A. Rosowsky, Joel E. Wright, Chitra M. Vaidya, Ronald A. Forsch

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Key concepts: Dihydrofolate reductase, Antifolate, Aminopterin, Chemistry, Biochemistry, Stereochemistry, Methotrexate, Amino acid

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The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine — Research Paper | ScholarLens