An overview of iron metabolism at a molecular level

Abstract Worwood M (Department of Haematology. University of Wales College of Medicine, Heath Park. Cardiff CF4 4XN, UK). An overview of iron metabolism at a molecular level. Over the last 10 years there has been steady progress in our understanding of the structure of the iron‐binding proteins transferrin and ferritin, and the transferrin receptor. In the last few years there have been very rapid developments in understanding of the genetics of these proteins and the regulation of synthesis. This review includes a description of gene localization and structure, the regulation of protein synthesis and the structure of proteins of the transferrin family, the transferrin receptor and the iron storage protein ferritin.