2007•Journal of Pharmacy & BioresourcesRequires access
Anti-anaemic activity of Spondias mombin and Khaya grandifoliola aqueous extracts on rats
A.A. Adeyemi, A. A. Gbolade
Open publisher page 3 citations
Abstract
Aqueous extracts of Spondias mombin leaf and Khaya grandifoliola stem bark at various doses were investigated for anti-anaemic activity in an in vivo model using albino rats. Activity was determined by measuring haematological parameters like packed cell volume (PCV), haemoglobin count (Hb) and white blood cell count (WBC). Anaemia was induced with by dosing control rats with 50 mg/ kg of chloramphenicol for two weeks. Oral administration of S. mombin extracts at doses of 100 -400 mg/kg to anaemic rats resulted in significant (P < 0.1) dose-dependent increases in PCV and Hb. Similar extracts of K. grandifoliola did not give significant (P>0.05) recovery from anaemia when tested at 50-200 mg/kg. A fall in WBC was recorded with both extracts. This investigation has validated the use of S. mombin as a haematinic in traditional medicine. Keywords: Spondias mombin, Khaya grandifoliola, haematological parameters, aqueous extract, anti-anaemic activity Journal of Pharmacy and Bioresources Vol. 3 (2) 2006: pp. 94-97