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2006•Química NovaOpen access

Alcalóides pirrolizidínicos em espécies do gênero Senecio

Chana de Medeiros da Silva, Aline Abati Bolzan, Berta Maria Heinzmann

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Abstract

PYRROLIZIDINE ALKALOIDS FROM Senecio SPECIES.Senecio species contain a large variety of secondary metabolites and many of these plants afford pyrrolizidine alkaloids.This paper is a review of the literature, describing 62 pyrrolizidine alkaloids already isolated in 62 of more than 2000 species of Senecio, distributed worldwide.The structure-activity relationships involving their toxicity are also discussed, since some Senecio species used for medicinal purposes are responsible for causing serious adverse effects.

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PYRROLIZIDINE ALKALOIDS FROM Senecio SPECIES.Senecio species contain a large variety of secondary metabolites and many of these plants afford pyrrolizidine alkaloids.This paper is a review of the literature, describing 62 pyrrolizidine alkaloids already isolated in 62 of more than 2000 species of Senecio, distributed worldwide.The structure-activity relationships involving their toxicity are also discussed, since some Senecio species used for medicinal purposes are responsible for causing serious adverse effects.

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Available abstract

PYRROLIZIDINE ALKALOIDS FROM Senecio SPECIES.Senecio species contain a large variety of secondary metabolites and many of these plants afford pyrrolizidine alkaloids.This paper is a review of the literature, describing 62 pyrrolizidine alkaloids already isolated in 62 of more than 2000 species of Senecio, distributed worldwide.The structure-activity relationships involving their toxicity are also discussed, since some Senecio species used for medicinal purposes are responsible for causing serious adverse effects.

Key concepts: Senecio, Pyrrolizidine, Biology, Botany

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