1971•European Journal of EndocrinologyRequires access

UPTAKE OF [1,2-3H] TESTOSTERONE IN OESTROGENIZED MALE RATS

J. Emmett Simmons

Abstract

ABSTRACT A decrease in uptake of tritiated testosterone by the hypothalamus was observed in adult, castrated male rats previously injected with 100 μg oestradiol undecylate on either postnatal days 1 or 5. Moreover, a decrease in pituitary incorporation of labelled testosterone was observed in those animals injected with oestradiol on day 1. Neonatal (5 day) male rats injected with oestradiol 3 hours prior to administering labelled testosterone showed a significant decrease in uptake of label in the pituitary and an increase in uptake by the hypothalamus as compared to oil injected controls. It is suggested that neonatal oestrogenization of male rats affects testosterone receptor mechanisms in the hypothalamus and/or pituitary.

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Key concepts: Internal medicine, Endocrinology, Hypothalamus, Testosterone (patch), Pituitary gland, Hypothalamic–pituitary–gonadal axis, Adult male, Chemistry