1999•Toxicological & Environmental Chemistry ReviewsRequires access

Acute/chronic ratios to estimate chronic toxicity from acute data

Liping Wei, Wen‐Hua Zhang, Shuokui Han, Liansheng Wang, Yuanhui Zhao

Abstract

Acute toxicity of 25 narcotic compounds to D. magna was determined in this paper. Acute/ Chronic Ratios (ACRs), which are often used to estimate chronic toxicity from acute toxicity data, are discussed based on Quantitative Structure‐Activity Relationships (QSARs) of the compounds between both acute and chronic toxicity data and n‐octanol/water partition coefficients, and an improved equation is derived to estimate chronic toxicity data from acute toxicity data. Application of the improved equation and ACRs is illustrated for D. magna and fathead minnow to estimate chronic toxicity from acute toxicity.

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Key concepts: Chronic toxicity, Acute toxicity, Toxicity, Minnow, Daphnia magna, Pharmacology, Toxicology, Chemistry