THE EFFECT OF BICUCULLINE, METRAZOL, PICROTOXIN AND STRYCHNINE ON THE RELEASE OF [3H]GABA FROM RAT BRAIN SLICES

Abstract— Each of the four convulsants used significantly influenced the release of [3H]‐GABA from brain slices, without affecting [3H]GABA uptake. Bicuculline (10−5M, but not 10‐fold higher or lower concentrations) potentiated the electrically evoked release of [3H]GABA but not the resting release, whereas metrazol (10−4 to 10−6 M) was found to inhibit resting but not electrically evoked release. Strychnine (10−4 and 10−5 M) and picro‐toxin (10−4 M) inhibited electrically evoked release.