1987•International Journal of NeuroscienceRequires access
Amantadine for Levodopa Resistant Parkinsonism
Reuven Sandyk, Robert Paul Iacono, Stuart R. Snider
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Abstract
A 65-year-old woman with stigmata of Parkinsonism was resistant to therapy with levodopa, bromocriptine and anticholinergics. However, administration of amantadine (Symmetrel), (200 mg/day) produced significant improvement in her motor disability as well as in her mental status. The mechanisms of amantadine's therapeutic effects in this unusual case are discussed.