2012•Optics ExpressOpen access

Quantitative phase contrast optimised cancerous cell differentiation via ptychography

Daniel Claus, Andrew Maiden, Fucai Zhang, F. Sweeney, Martin J. Humphry, Hermann J. Schluesener, John Marius Rodenburg

Abstract

This paper shows that visible-light ptychography can be used to distinguish quantitatively between healthy and tumorous unstained cells. Advantages of ptychography in comparison to conventional phase-sensitive imaging techniques are highlighted. A novel procedure to automatically refocus ptychographic reconstructions is also presented, which improves quantitative analysis.

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Available abstract

Key concepts: Ptychography, Optics, Phase retrieval, Contrast (vision), Phase (matter), Phase contrast microscopy, Phase-contrast imaging, Phase imaging