1989•Molecular MicrobiologyOpen access

Genetics of pertussis toxin

Roy Gross, Beatrice Aricò, Rino Rappuoli

Abstract

Pertussis toxin (PT) is the major virulence factor of Bordetella pertussis. The cloning and nucleotide sequencing of the PT genes from B. pertussis, Bordetella parapertussis and Bordetella bronchiseptica has elucidated the evolution of the Bordetella species and allowed considerable advances towards the understanding of their gene expression and the development of safer vaccines against pertussis.

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Key concepts: Bordetella pertussis, Biology, Bordetella, Pertussis toxin, Bordetella bronchiseptica, Virulence, Microbiology, Virulence factor