1998•Hormone and Metabolic ResearchRequires access

Insulin Resistance, Dehydroepiandrosterone Sulfate and Sex Hormone-Binding Globulin in Essential Hypertension*

Joaquín Serrano Gotarredona, Héctor Francisco Escobar-Morreale, J. Sancho, Rafael García‐Robles

Abstract

OBJECTIVE: To evaluate insulin sensitivity, and serum levels of sex hormone-binding globulin (SHBG) and dehydroepiandrosterone sulfate (DHEA-sulfate), in patients with essential hypertension. DESIGN AND METHODS: In 15 non-treated hypertensive patients, insulin resistance was measured by an insulin suppression test (IST). Serum levels of DHEA-sulfate and SHBG were measured at the beginning and at the end of the IST. The results were compared to those of a control group of 10 healthy normotensive subjects matched for age, sex and body mass index (BMI).

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Key concepts: Sex hormone-binding globulin, Dehydroepiandrosterone sulfate, Internal medicine, Endocrinology, Insulin resistance, Body mass index, Dehydroepiandrosterone, Insulin