CONTROL OF HEPATIC FRUCTOSE‐METABOLIZING ENZYMES: FRUCTOKINASE, ALDOLASE AND TRIOKINASE

Abstract. Physiological factors which may regulate the catalytic activity of three key enzymes of hepatic fructose metabolism, fructokinase, aldolase and triokinase, are reviewed. Possible relationships between these potential control mechanisms and hepatic fructose metabolism per se are discussed at three distinct levels: 1) characterization in vitro of purified enzyme preparations; 2) variation of enzyme activity in vivo under various dietary and hormonal conditions; and 3) variation of enzyme activity in vivo following development of liver tumors of different growth rate and degree of cellular differentiation.