2005•Angewandte Chemie International EditionRequires access

Cellular Profiling of Small‐Molecule Bioactivities: an Alternative Tool for Chemical Biology

Thorsten Berg

Abstract

Are they a good match? Target identification is critical to the success of chemical genetics projects that start with phenotypic screens. The method highlighted herein is a novel way to decrease the number of potential biological targets of compounds identified in phenotypic screens by comparison of their cellular activity profiles with those obtained with reference compounds. Activity profiles for hypothetical compounds A and B are shown.

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Available abstract

Key concepts: Profiling (computer programming), Computational biology, Phenotype, Small molecule, Chemical biology, Chemical genetics, Identification (biology), Phenotypic screening