2003•Annals of the New York Academy of SciencesRequires access
Activation‐Induced Cytidine Deaminase Links Class Switch Recombination and Somatic Hypermutation
Il‐mi Okazaki, Kiyotsugu Yoshikawa, Kazuo Kinoshita, Masamichi Muramatsu, Hitoshi Nagaoka, Tasuku Honjo
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Abstract
Activation-induced cytidine deaminase (AID), a putative RNA-editing cytidine deaiminase that is expressed strictly in activated B cells, is indispensable in three apparently distinct genetic alterations of immunoglobulin genes-namely, class switch recombination, somatic hypermutation, and gene conversion. Recent findings led us to propose a common DNA cleaving mechanism, in which the transient secondary structure of the S and V region DNA is recognized by a nicking enzyme regulated by the putative RNA-editing activity of AID.