Pharmacokinetics of propranolol in the dog

The pharmacokinetics of propranolol were investigated in dogs following intravenous, single oral, and multiple oral doses. Mean half‐life of the compound following single intravenous administration was 1.09 h, following single oral dose 1.58 h, and 2.14 h after chronic oral dosing. Half‐life values previously reported in dogs for the levo and dextro isomers were 0.77 and 1.08h, respectively. The bioavailability of oral propranolol was low (2–17% available) following a single oral dose, but increased substantially after chronic oral dosing, suggesting saturation of the disposition processes for propranolol with multiple dosing regimens.