2010•Journal of Combinatorial ChemistryRequires access

Regio- and Stereoselective Synthesis of Novel Dispiropyrrolidine Bisoxindole Derivatives via Multicomponent Reactions

Hai Liu, Guolan Dou, Daqing Shi

Abstract

A convenient and efficient method for the synthesis of novel dispiropyrrolidine bisoxindole derivatives by 1,3-dipolar cycloaddition reaction of azomethine ylides has been developed. The synthesis was achieved by using a one-pot multicomponent procedure. The features of this procedure were characterized by the following: mild reaction conditions, high yields, high regio- and stereoselectivity, one-pot procedure, and operational simplicity.

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Key concepts: Stereoselectivity, Cycloaddition, Chemistry, Combinatorial chemistry, Reaction conditions, 1,3-Dipolar cycloaddition, Organic chemistry, Catalysis