1985•MicrobiologyRequires access

Fosfomycin-resistance Plasmids Determine an Intracellular Modification of Fosfomycin

Javier León, Juan M. Garcı́a-Lobo, Jesús Navas, José Ortíz

Abstract

Escherichia coli cells carrying fosfomycin-resistance plasmids modify fosfomycin intracellularly. The product of this modification (fosfomycin-derivative) differs from fosfomycin in chromatographic mobility, but the chemical nature of the modification is not yet known. Fosfomycin-derivative appears to have a cytoplasmic location and lacks antibiotic activity. The modification system can be saturated by an excess of fosfomycin in the incubation media.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 14 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Fosfomycin, Escherichia coli, Plasmid, Microbiology, Chemistry, Cytoplasm, Intracellular, Antibiotics