1992•FEBS LettersOpen access

Interferon‐mediated intracellular signalling Modulation of different phospholipase activities in Burkitt lymphoma cells

Amelia Cataldi, R. Rana, Roberto Di Primio, Renato Bareggi, R. Lisio, Noura A. Toto, Sebastianó Miscia

Abstract

The effect of interferon-alpha on Daudi lymphoma cells either sensitive or resistant to the action of this cytokine has been analysed in terms of phospholipase C (PLC) and D (PLD) activities. Results have shown a combined modulation of PIP2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signalling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway.

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Key concepts: Phospholipase C, Phospholipase D, Phospholipase, Intracellular, Chemistry, Phosphatidylcholine, Interferon, Lymphoma