1962•ScienceRequires access
Myo-inositol in the Biosynthesis of Streptomycin by Streptomyces griseus
S. K. Majumdar, H. J. Kutzner
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Abstract
When myo-inositol is present in a growing culture of Streptomyces griseus the yield of streptomycin is increased, and the amount of carbon-14-from uniformly labeled glucose-incorporated into the streptidine and streptobiosamine moieties of streptomycin is lowered by 41 percent and 21.7 percent, respectively. These results present strong indirect evidence for the participation of myo-inositol or its metabolic products in streptidine biosynthesis.