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2008•Palliative MedicineRequires access

Opioid withdrawal syndrome on switching from hydromorphone to alfentanil

F McMunnigall, John Welsh

Open publisher page 7 citations

Abstract

Opioid switching is increasingly practiced. This patient did not tolerate morphine, oxycodone or hydromorphone due to opioid toxicity. Finally switch to alfentanil was performed. The patient developed classical opioid withdrawal symptoms and signs from discontinuation of the hydromorphone. Administration of small aliqouts of this drug reversed the symptoms. The existance of incomplete cross tolerance between hydromorphone and alfentanil is demonstrated.

About this research paper

What this paper is about

Opioid switching is increasingly practiced. This patient did not tolerate morphine, oxycodone or hydromorphone due to opioid toxicity. Finally switch to alfentanil was performed. The patient developed classical opioid withdrawal symptoms and signs from discontinuation of the hydromorphone. Administration of small aliqouts of this drug reversed the symptoms. The existance of incomplete cross tolerance between hydromorphone and alfentanil is demonstrated.

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Opioid switching is increasingly practiced. This patient did not tolerate morphine, oxycodone or hydromorphone due to opioid toxicity. Finally switch to alfentanil was performed. The patient developed classical opioid withdrawal symptoms and signs from discontinuation of the hydromorphone. Administration of small aliqouts of this drug reversed the symptoms. The existance of incomplete cross tolerance between hydromorphone and alfentanil is demonstrated.

Key concepts: Hydromorphone, Alfentanil, Medicine, Oxycodone, Discontinuation, Opioid, Anesthesia, Morphine

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