2010•Seminars in NeurologyRequires access

Treatment of Chronic Immune-mediated Neuropathies: Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Multifocal Motor Neuropathy, and the Lewis-Sumner Syndrome

Benson Sederholm

Abstract

Current treatment approaches for the management of chronic immune-mediated peripheral neuropathies are reviewed, including chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN), and the Lewis-Sumner syndrome (LSS). A summary of existing evidence for commonly used treatment modalities, such as corticosteroids, intravenous immune globulin (IVIG), and plasma exchange is provided. Evidence for the use of additional immunosuppressant and immunomodulatory agents is also reviewed. KEYWORDS Chronic inflammatory demyelinating polyradiculoneuropathy - multifocal motor neuropathy - Lewis-Sumner syndrome - intravenous immune globulin - plasma exchange - corticosteroids

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Key concepts: Polyradiculoneuropathy, Multifocal motor neuropathy, Medicine, Immune system, Immunology, Chronic inflammatory demyelinating polyneuropathy, Peripheral neuropathy, Guillain-Barre syndrome