2012•European Journal of ChemistryOpen access

Knoevenagel condensation of isatins with malononitrile/ethyl cyanoacetate in the presence of sulfonic acid functionalized silica (SBA-Pr-SO3H) as a new nano-reactor

Negar Lashgari, Ghodsi Mohammadi Ziarani, Alireza Badiei, Parisa Gholamzadeh

Abstract

The Knoevenagel condensation between isatins and active methylene compounds like malononitrile and ethyl cyanoacetate to prepare 2-oxoindolin-3-ylidene malononitrile/ cyanoacetates is described. The reactions occur in the presence of sulfonic acid functionalized silica SBA-15 (SBA-Pr-SO 3 H) in an aqueous medium giving excellent yields of the products in short reaction times. SBA-Pr-SO 3 H with a pore size of 6 nm is found to be an efficient and environmentally benign catalyst for this reaction.

Open-access reader

About this research paper

What this paper is about

Why it matters

OpenAlex reports 23 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Malononitrile, Knoevenagel condensation, Chemistry, Sulfonic acid, Ethyl cyanoacetate, Catalysis, Methylene, Organic chemistry