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1986•Archives of Otolaryngology - Head and Neck SurgeryRequires access

Cefazolin vs Moxalactam? A Double-blind Randomized Trial of Cephalosporins in Head and Neck Surgery

James T. Johnson, Victor L. Yu, E. N. Myers, Robin L. Wagner, B. A. Sigler

Open publisher page 37 citations

Abstract

Cefazolin and moxalactam were compared in a prospective randomized double-blind trial of 118 patients undergoing oncologic head and neck surgery. Both antibiotics were given 2 g every four hours for four doses. Five infections were encountered in the cefazolin group (8.5%) and two infections in the moxalactam group (3.4%); this difference was not statistically significant. This assessment does not indicate, however, that the two regimens are equally efficacious.

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What this paper is about

Cefazolin and moxalactam were compared in a prospective randomized double-blind trial of 118 patients undergoing oncologic head and neck surgery. Both antibiotics were given 2 g every four hours for four doses. Five infections were encountered in the cefazolin group (8.5%) and two infections in the moxalactam group (3.4%); this difference was not statistically significant. This assessment does not indicate, however, that the two regimens are equally efficacious.

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OpenAlex reports 37 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Cefazolin and moxalactam were compared in a prospective randomized double-blind trial of 118 patients undergoing oncologic head and neck surgery. Both antibiotics were given 2 g every four hours for four doses. Five infections were encountered in the cefazolin group (8.5%) and two infections in the moxalactam group (3.4%); this difference was not statistically significant. This assessment does not indicate, however, that the two regimens are equally efficacious.

Key concepts: Moxalactam, Cefazolin, Medicine, Cephalosporin, Surgery, Anesthesia, Randomized controlled trial, Latamoxef

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