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2013•Clinical TherapeuticsOpen access

PP142—Influence of the CYP2D6 -1584C>G promoter polymorphism on the phenotype of debrisoquine in healthy volunteers from Cuba and Nicaragua

M.E.G. Naranjo, Pedro Dorado, Luis R. Calzadilla, M. Álvarez, Ronald Ramírez, Eva Peñas‐Lledó, B Pérez, Idilio González, Adrián LLerena

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Abstract

Ultrarapid drug metabolism (UM) mediated by CYP2D6 is associated with duplicated or amplified functional CYP2D6 alleles. However, duplicated CYP2D6 alleles only explains a fraction (10%–30%) of the UM phenotype observed in Caucasian populations, and other biochemical and/or genetic factors involved in UM phenotype remain unexplained yet. CYP2D6 -1584C>G has been related with changes in CYP2D6 expression, being -1584G associated with higher expression. The aim of this study was to explore the relationship between CYP2D6 -1584C>G polymorphism and the debrisoquine hydroxylation capacity.

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What this paper is about

Ultrarapid drug metabolism (UM) mediated by CYP2D6 is associated with duplicated or amplified functional CYP2D6 alleles. However, duplicated CYP2D6 alleles only explains a fraction (10%–30%) of the UM phenotype observed in Caucasian populations, and other biochemical and/or genetic factors involved in UM phenotype remain unexplained yet. CYP2D6 -1584C>G has been related with changes in CYP2D6 expression, being -1584G associated with higher expression. The aim of this study was to explore the relationship between CYP2D6 -1584C>G polymorphism and the debrisoquine hydroxylation capacity.

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Available abstract

Ultrarapid drug metabolism (UM) mediated by CYP2D6 is associated with duplicated or amplified functional CYP2D6 alleles. However, duplicated CYP2D6 alleles only explains a fraction (10%–30%) of the UM phenotype observed in Caucasian populations, and other biochemical and/or genetic factors involved in UM phenotype remain unexplained yet. CYP2D6 -1584C>G has been related with changes in CYP2D6 expression, being -1584G associated with higher expression. The aim of this study was to explore the relationship between CYP2D6 -1584C>G polymorphism and the debrisoquine hydroxylation capacity.

Key concepts: Debrisoquine, CYP2D6, Phenotype, Allele, Genetics, Polymorphism (computer science), Medicine, Hydroxylation

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PP142—Influence of the CYP2D6 -1584C>G promoter polymorphism on the phenotype of debrisoquine in healthy volunteers from Cuba and Nicaragua — Research Paper | ScholarLens