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Effect of imipramine and some analogues on the uptake of 5-hydroxytryptamine by human blood platelets in vitro

Celia M. Yates, A Todrick, A. C. Tait

Open publisher page 30 citations

Abstract

Abstract The inhibitory action of imipramine and some analogues on the uptake of 5-hydroxytryptamine by human blood platelets in vitro was investigated. In concentrations comparable with those reached in plasma during therapy, imipramine and the isosteric compound, amitriptyline, were more effective than their metabolites. Chlorpromazine was less effective than the latter and orphenadrine ineffective at the concentrations tested.

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What this paper is about

Abstract The inhibitory action of imipramine and some analogues on the uptake of 5-hydroxytryptamine by human blood platelets in vitro was investigated. In concentrations comparable with those reached in plasma during therapy, imipramine and the isosteric compound, amitriptyline, were more effective than their metabolites. Chlorpromazine was less effective than the latter and orphenadrine ineffective at the concentrations tested.

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Available abstract

Abstract The inhibitory action of imipramine and some analogues on the uptake of 5-hydroxytryptamine by human blood platelets in vitro was investigated. In concentrations comparable with those reached in plasma during therapy, imipramine and the isosteric compound, amitriptyline, were more effective than their metabolites. Chlorpromazine was less effective than the latter and orphenadrine ineffective at the concentrations tested.

Key concepts: Imipramine, Platelet, Pharmacology, In vitro, Chlorpromazine, Amitriptyline, Chemistry, Human blood

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Effect of imipramine and some analogues on the uptake of 5-hydroxytryptamine by human blood platelets in vitro — Research Paper | ScholarLens