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A gas-liquid chromatographic method for the quantitative determination of tolmetin in plasma and tolmetin and its major metabolite in urine.

M.L. Selley, J. Thomas, E. J. Triggs

Abstract

Abstract A sensitive and specific gas chromatographic method for the determination of the non-steroidal anti-inflammatory drug tolmetin in human plasma and tolmetin and its major metabolite in human urine is described. The compounds were extracted as acids into diethyl ether and after a clean-up procedure converted to their methyl esters and separated on a gas chromatograph equipped with a flame ionizaiton detector. The method has been applied to samples of plasma and urine from subjects receiving tolmetin under experimental and therapeutic conditions.

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Key concepts: Chemistry, Chromatography, Metabolite, Urine, Diethyl ether, Gas chromatography, Ether, Biological fluids