1992•Chinese Journal of Cancer ResearchRequires access

Simultaneous over-expression of insulin-like growth factor-II (IGF II) and IGF-II receptor (IGF-II R) genes in human primary cancer-implication of autocrine and paracrine mechanism in autonomous growth of hepatic cancer

Xiaomei Zhou, Jianren Gu, Yuanqing Cheng, Jiang Huiqiu, Qian Lianfang, Guowei Xu, Shafritz David

Abstract

This is first report about the simultaneous over-expression of both Insulin-like growth factor (IGF-II) and its receptor (IGF-II R) at mRNA level in human primary hepatic Cancer (PHC). In 10 PHC samples from China, IGF-II and IGF-II R were both over-expressed, whereas only a background signal was detected in normal liver. In 5 pairs of PHC and its non-tumorous adjacent liver tissues from South Africa, IGF-II and IGF-II R were also over-expressed in PHC. mRNA expression of IGF-II in all 5 cases and IGF-II R in 4 of 5 cases were higher in cancer than non-tumorous adjacent liver tissues. These results strongly implicate that an autocrine and/or paracrine mechanism might be involved in formation and progression of PHC.

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Key concepts: Autocrine signalling, Paracrine signalling, Insulin-like growth factor, Growth factor, Insulin-like growth factor 2, Receptor, Cancer research, Messenger RNA