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Experimental research on the anti-cancer immunomodulative effect of the polysocoharibe-peptide of coriolus versicolor

Liangzhong Xu, Yang Qingyao, Jinxu Zhou, Ruiting Chen, Xiaoyu Li, Yujuan Hu, Junmo Wang

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Abstract

Polysocoharibe-peptide of Coriolus Versicolor (PSP) is a new anti-cancer immunomodulative drug. The present paper reports on the experimental research done with this drug. It was found that PSP had the ability to recover hemolysin HC50, to increase the weight of the thymus, and increase the alexin of serum C3 and the IgG content of tumor bearing mice. PSP also significantly raised the phagocytic activity of macrophages in normal mice. PSP had a significant inhibitory effect on P388 and S 180 cells. At the concentration of 1 mg/ml, PSP inhibited the proliferating activity of some human tumor cell lines, such as SGC 7901, SPC, SLY and Mei. It had a direct toxic effect on SPC cells. PSP significantly inhibited the synthesis of nucleic acids of Ehrlich ascites carcinoma cells. In addition, PSP was antagonistic to the side effects of chemotherapy and radiotherapy.

About this research paper

What this paper is about

Polysocoharibe-peptide of Coriolus Versicolor (PSP) is a new anti-cancer immunomodulative drug. The present paper reports on the experimental research done with this drug. It was found that PSP had the ability to recover hemolysin HC50, to increase the weight of the thymus, and increase the alexin of serum C3 and the IgG content of tumor bearing mice. PSP also significantly raised the phagocytic activity of macrophages in normal mice. PSP had a significant inhibitory effect on P388 and S 180 cells. At the concentration of 1 mg/ml, PSP inhibited the proliferating activity of some human tumor cell lines, such as SGC 7901, SPC, SLY and Mei. It had a direct toxic effect on SPC cells. PSP significantly inhibited the synthesis of nucleic acids of Ehrlich ascites carcinoma cells. In addition, PSP was antagonistic to the side effects of chemotherapy and radiotherapy.

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OpenAlex reports 5 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Polysocoharibe-peptide of Coriolus Versicolor (PSP) is a new anti-cancer immunomodulative drug. The present paper reports on the experimental research done with this drug. It was found that PSP had the ability to recover hemolysin HC50, to increase the weight of the thymus, and increase the alexin of serum C3 and the IgG content of tumor bearing mice. PSP also significantly raised the phagocytic activity of macrophages in normal mice. PSP had a significant inhibitory effect on P388 and S 180 cells. At the concentration of 1 mg/ml, PSP inhibited the proliferating activity of some human tumor cell lines, such as SGC 7901, SPC, SLY and Mei. It had a direct toxic effect on SPC cells. PSP significantly inhibited the synthesis of nucleic acids of Ehrlich ascites carcinoma cells. In addition, PSP was antagonistic to the side effects of chemotherapy and radiotherapy.

Key concepts: Ehrlich ascites carcinoma, Cancer cell, Hemolysin, Peptide, Nucleic acid, Pharmacology, Chemistry, Drug

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Experimental research on the anti-cancer immunomodulative effect of the polysocoharibe-peptide of coriolus versicolor — Research Paper | ScholarLens