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2015•Lab on a ChipOpen access

Miniaturization of a micro-optics array for highly sensitive and parallel detection on an injection moulded lab-on-a-chip

Tran Quang Hung, Yi Sun, Carl Esben Poulsen, Than Linh Quyen, Wai Hoe Chin, Dang Duong Bang, Anders Wolff

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Abstract

A miniaturised array of supercritical angle fluorescence (SAF) micro-optics embedded in a microfluidic chamber was fabricated by injection moulding. The fabricated chip could enhance the fluorescence signal around 46 times compared to a conventional microscope. Collection of the fluorescence signal from the SAF array is almost independent of the numerical aperture, and the limit of detection was improved 36-fold using a simple and inexpensive optical detection system.

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What this paper is about

A miniaturised array of supercritical angle fluorescence (SAF) micro-optics embedded in a microfluidic chamber was fabricated by injection moulding. The fabricated chip could enhance the fluorescence signal around 46 times compared to a conventional microscope. Collection of the fluorescence signal from the SAF array is almost independent of the numerical aperture, and the limit of detection was improved 36-fold using a simple and inexpensive optical detection system.

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Available abstract

A miniaturised array of supercritical angle fluorescence (SAF) micro-optics embedded in a microfluidic chamber was fabricated by injection moulding. The fabricated chip could enhance the fluorescence signal around 46 times compared to a conventional microscope. Collection of the fluorescence signal from the SAF array is almost independent of the numerical aperture, and the limit of detection was improved 36-fold using a simple and inexpensive optical detection system.

Key concepts: Miniaturization, Lab-on-a-chip, Chip, Microfluidics, Multiplexing, Sensitivity (control systems), Nanotechnology, Materials science

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