The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein–protein interactions
Peter van der Geer, Sandra E. Wiley, Gerald Gish, Tony Pawson
Abstract
Peter van der Geer, Sandra E. Wiley, Gerald Gish, Tony Pawson
Abstract
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Key concepts: SH2 domain, Phosphotyrosine-binding domain, GRB2, Biology, Signal transducing adaptor protein, Proto-oncogene tyrosine-protein kinase Src, SH3 domain, Protein tyrosine phosphatase