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2001•Cell Biology InternationalRequires access

INHIBITION OF THE CONTRACTION OF COLLAGEN GELS BY EXTRACTS FROM HUMAN DERMIS

Mohamed A El-Sheemy, I.F.K. Muir, Denys N. Wheatley, Oleg Eremin

Open publisher page 7 citations

Abstract

Extracts from the human dermis were prepared and evaluated with respect to their ability to influence fibroblasts to contract collagen gels in vitro. The extract which had the most inhibitory effect on fibroblasts to cause contraction of collagen gels was extract D. It also inhibited fibroblast growth. Inhibition of contraction was not simply related to fibroblast cell numbers and the data suggests a specific effect upon the ability of fibroblasts to cause contraction. Other extracts were without significant effect.

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What this paper is about

Extracts from the human dermis were prepared and evaluated with respect to their ability to influence fibroblasts to contract collagen gels in vitro. The extract which had the most inhibitory effect on fibroblasts to cause contraction of collagen gels was extract D. It also inhibited fibroblast growth. Inhibition of contraction was not simply related to fibroblast cell numbers and the data suggests a specific effect upon the ability of fibroblasts to cause contraction. Other extracts were without significant effect.

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Extracts from the human dermis were prepared and evaluated with respect to their ability to influence fibroblasts to contract collagen gels in vitro. The extract which had the most inhibitory effect on fibroblasts to cause contraction of collagen gels was extract D. It also inhibited fibroblast growth. Inhibition of contraction was not simply related to fibroblast cell numbers and the data suggests a specific effect upon the ability of fibroblasts to cause contraction. Other extracts were without significant effect.

Key concepts: Fibroblast, Dermis, Contraction (grammar), Dermal fibroblast, In vitro, Chemistry, Cell biology, Biochemistry

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INHIBITION OF THE CONTRACTION OF COLLAGEN GELS BY EXTRACTS FROM HUMAN DERMIS — Research Paper | ScholarLens